Given that c-Myc may serve as a potential downstream gene of NPM1 (Fig. 3) and that the binding of BRD4 to c-Myc was decreased when NPM1 was knocked down but increased when NPM1 was overexpressed in PCa cells (Fig. 5D‒G), we hypothesized that NPM1 may influence and cooperate with BRD4 to facilitate downstream target transcription. Here, NPM1 is linked to posterior cortical atrophy.