To investigate whether DNAJA4 promotes MYH9 protein degradation and thus exerts an inhibitory effect on NPC cell migration, invasion, and EMT, we co-transfected the DNAJA4 overexpression plasmid with the MYH9 overexpression plasmid into HONE1 and SUNE1 cells. The gene discussed is DNAJA4; the disease is nasopharyngeal carcinoma.