DNAJA4 and nasopharyngeal carcinoma: To verify whether the CpG island of DNAJA4 is hypermethylated in NPC, we measured the methylation level of cg16358679, the most significantly hypermethylated CpG site in the CpG island of DNAJA4, in another 6 NPC and 6 normal nasopharynx tissues by pyrophosphate sequencing, and the results showed that the methylation level of cg16358679 was obviously increased in NPC tissues (Fig. 1D).