Moreover, we performed denaturing-IP after rescue transfection to test whether the ubiquitination of MYH9 mediated by DNAJA4 is affected by PSMD2, and the results showed that knockdown of PSMD2 reversed the exogenous polyubiquitination of MYH9 mediated by DNAJA4 in NPC cells (Fig. 5H). This evidence concerns the gene MYH9 and nasopharyngeal carcinoma.