In our previous microarray data (GSE52068), five CpG sites of the DNAJA4 gene (cg16358679, cg17246382, cg01786994, cg05392364 and cg22935921), all of which were located within the CpG island, were found to be significantly hypermethylated in NPC tissues compared to normal nasopharynx tissues (Fig. 1B). The gene discussed is DNAJA4; the disease is nasopharyngeal carcinoma.