In order to find out whether LDHA has a pivotal role in the PC progression mediated by FOXQ1, siRNA of LDHA (si-LDHA) and 2-deoxy-d-glucose (2-DG, the glycolysis inhibitors, 100 mM) were added into the FOXQ1 overexpressing PC cells. Here, LDHA is linked to pachyonychia congenita.