However, pretreatment with anti-HSP70 antibody significantly abrogated the phagocytosis of DOX@3D-MPs-treated tumor cells by moDCs (Fig. 8b) and the subsequent moDC maturation (Fig. 8c, d), as well as CD8+ T cell activation (Fig. 8e–g) and cytotoxicity against tumor cells (Fig. 8h), revealing that HSP70 in 3D-MPs was responsible for DOX@3D-MPs-induced immunogenic activation for tumor inhibition. The gene discussed is CD8A; the disease is neoplasm.