PDCD1 and neoplasm: Moreover, the potent antitumor effects of DOX@3D-MPs+anti-PD-1 was additionally detected in mice bearing large established H22 tumor with the initial tumor sizes of 250 mm3, with 94.9% and 82.9% reduction in tumor volume (Supplementary Fig. 27a) and weight (Supplementary Fig. 27b), as well as much higher survival rate (Supplementary Fig. 27c).