Importantly, DOX@3D-MPs treatment significantly enhanced the amounts of central memory T (Tcm) cells (CD8+CD44+CD62L+ T cells) and effector memory T (Tem) cells (CD8+CD44+CD62L- T cells) in the spleens (Fig. 4k, l) and TDLNs (Supplementary Fig. 16a, b) of H22 tumor-inoculated mice compared with mice administrated with other treatments, demonstrating that DOX@3D-MPs might effectively induce antitumor immune memory. Here, SELL is linked to neoplasm.