TNF and neoplasm: Consistently, knocking out HSP70 in 3D-MPs significantly abrogated the DOX@3D-MPs-evoked increase in the amounts of CD11c+CD80+CD86+ (Fig. 6e), CD11c+MHC-II+ (Fig. 6f), CD8+ T (Fig. 6g), proliferative CD8+Ki67+ T (Fig. 6h), and activated CD8+CD69+ T (Fig. 6i), CD8+IL-2+ T (Fig. 6j), CD8+IFN-γ+ T (Fig. 6k), CD8+TNF-α+ T (Fig. 6l) and CD8+GzmB+ T cells (Fig. 6m) within tumor tissues, suggesting that HSP70 in 3D-MPs played an important role in DOX@3D-MPs-induced DC maturation as well as activation of CD8+ T cells within TIM.