Moreover, the ratios of CD69+ (Fig. 8e), INF-γ+ (Fig. 8f) and GzmB+ cells (Fig. 8g) in CD8+ T cells were obviously upregulated when T cells isolated from healthy PBMCs were incubated with the above moDCs matured by DOX@3D-MPs-treated tumor cells. The gene discussed is CD69; the disease is neoplasm.