The EAE model is particularly well-suited for examining the autoimmune mechanisms underlying MS, making it a valuable tool for investigating experimental treatments.7 Both WT and eEF2K KO mice were subjected to subcutaneous immunization using myelin oligodendrocyte glycoprotein (MOG35-55), which was suspended in an emulsion with complete Freund’s adjuvant (CFA), along with intraperitoneal injections of pertussis toxin to induce EAE. Here, MOG is linked to myeloid sarcoma.