FOXA2 has been recognized to be ubiquitinated to control its protein expression and degradation.[39] We finally found that the down‐regulation of E3 ligase TRIM36 during CRC progression might largely contribute to the K48‐linked polyubiquitination of FOXA2, thereby resulting in FOXA2 degradation and the subsequent effects on CRC growth. Here, FOXA2 is linked to colorectal carcinoma.