As expected, RT‐qPCR results indicated that FOXA2 deletion significantly reduced the mRNA expression levels of Nrf2, GCLC, NQO1, SOD1, GPX4, SLC7A11, and G6PD in CRC cell lines, while its over‐expression led to the opposite result of these genes (Figure 3B). This evidence concerns the gene GPX4 and colorectal carcinoma.