CCK‐8 results showed that sh‐FOXA2‐reduced cell viability was significantly rescued upon Fer‐1 addition, while Nec‐1 and Z‐VAD‐FMK treatments had no influence on the changes in cell viability interfered by sh‐FOXA2 (Figure 4H), indicating that FOXA2 deletion‐restrained CRC proliferation might be largely through the process of ferroptosis induction. Here, PCSK1 is linked to colorectal carcinoma.