FOXA2 and colorectal carcinoma: FOXA2 has been reported to be ubiquitinated for its protein degradation.[39] E3 ligases can regulate the polyubiquitination of substrates in cells and are involved in cellular signaling, proliferation, cell death, protein stability control, EMT, and carcinogenesis.[40] Therefore, we attempted to explore which one of these identified E3 ligases might be particularly important in the modulation of FOXA2 stability and expression during CRC progression.