The decreased expression of GPX4, Nrf2, and NQO1 induced by sh‐FOXA2 was validated by IF staining and western blot assays in CRC cells, but oe‐FOXA2 resulted in significant increases of GPX4, Nrf2 and NQO1 (Figure 3C‐E). Here, GPX4 is linked to colorectal carcinoma.