EMT is a program of epithelial cells to obtain a mesenchymal‐like phenotype, which can limit total surgical resection and result in therapeutic resistance, ultimately causing tumor recurrence.[45] Methods to restrain the EMT process are effective for the suppression of invasion and metastasis of numerous types of tumor cells, including CRC.[46] Recently, FOXA2 was initially identified to play an oncogene role in CRC by facilitating EMT and metastasis.[26] Consistently, we provided further support that FOXA2 up‐regulation was indeed involved in CRC progression. Here, FOXA2 is linked to neoplasm.