Finally, to examine whether other types of cell death were involved in FOXA2 knockdown‐inhibited CRC cell proliferation, ferroptosis, necroptosis, and apoptosis inhibitors, including Fer‐1, Nec‐1, and Z‐VAD‐FMK, respectively, were subjected to HCT‐116 and SW480 cells with or without sh‐FOXA2 transfection. This evidence concerns the gene PCSK1 and colorectal carcinoma.