As shown in Figure3A, significant positive correlations between FOXA2 gene expression and GPX4, NFE2L2 (Nrf2), NQO1, G6PD, and SLC7A11 were detected by Spearman analysis, revealing the potentially negative effects of FOXA2 on ferroptotic cell death in CRC. The gene discussed is NFE2L2; the disease is colorectal carcinoma.