FOXA2 and infectious otitis media: In the present study, we further explored the role of FOXA2 in drug‐sensitive and ‐resistant CRC cell lines and in the constructed xenograft mouse model, AOM/DSS‐induced CAC tumorigenesis using the intestinal‐specific FOXA2‐knockout mice, and the ApcMin/+ mouse model with CRC to uncover the involved molecular mechanisms.