Consistently, significant lipid ROS accumulation was identified in HCT‐116 and SW480 cells with FOXA knockdown compared with the sh‐NC group; however, CRC cells over‐expressing FOXA2 exerted markedly reduced lipid ROS by C11‐BODIPY581/591 staining (Figure 4C,D). The gene discussed is FOXA2; the disease is colorectal carcinoma.