Nrf2 is a major modulator of the antioxidant response, which contributes to its anti‐ferroptotic activity by regulating its target genes, such as NQO1, GCLC, and SLC7A11.[55] Increasing studies have noticed that Nrf2 signaling suppression could enhance the sensitivity of tumor cells to ferroptosis, while its activation contributed to ferroptosis resistance.[56, 57] In addition, GPX4, the only reported enzyme and a downstream target gene of Nrf2, can be capable of directly lessening complex phospholipid hydroperoxides. This evidence concerns the gene NFE2L2 and neoplasm.