NFE2L2 and colorectal carcinoma: Because GPX4 is particularly involved in ferroptotic cell death and is a key transcriptional target gene of Nrf2.[4, 5, 36] Then, the GPX4 inhibitor RSL3 was subjected to HCT‐116 and SW480 cells to further explore if ferroptosis participated in the drug sensitivity of CRC cells to OXA.