Our previous study found that CYP2E1 could be a new anti‐inflammatory target in sepsis and glioblastoma.[33, 34] We synthesized a novel CYP2E1 inhibitor, 1‐(4‐methyl‐5‐thialzolyl) ethenone, named Q11 with high selectivity and an inhibitory constant Ki for CYP2E1 of less than 1 μM. The gene discussed is CYP2E1; the disease is Sepsis.