Long‐term CYP2E1 inhibition by Q11 showed a good safety profile.[33] And we found that Q11 is effective in sepsis mouse model and GBM mouse model via the anti‐inflammation effect.[33, 34] In this study, we investigated the role of CYP2E1 in lung cancer, evaluated the effect of Q11 on lung cancer and identified the mechanism. This evidence concerns the gene CYP2E1 and lung cancer.