CYP2E1 and pulmonary emphysema: Furthermore, CYP2E1 has been reported to be closely related to pulmonary fibrosis, emphysema, and other lung diseases.[30] Epidemiological studies show that a CYP2E1 gene polymorphism is associated with lung cancer susceptibility.[31] Thus, it is worthy of further study whether CYP2E1 could be a potential inflammatory target in the lung tumor inflammatory microenvironment.