In addition, we analyzed the frequency of CD8+CD27+CXCR3− T cells from another unpaired SLE samples including 10 aSLE and 15 rSLE, similarly showing the significant increase in the rSLE samples, compared with aSLE samples, which further verified our discovery (Supplementary Figure S6d). The gene discussed is CD8A; the disease is systemic lupus erythematosus.