CD8A and systemic lupus erythematosus: To comprehensively profile the complexity of immune cell dysregulation across the disease spectrum and further investigate CD8+ T cells involvement in SLE diseased progression, we further analyzed 29 functional protein biomarkers in HCs, treatment‐naïve aSLE and rSLE by CyTOF (Tables S1,S2,S3 and Figure S1, Supporting Information).