ME induced gene and deletion mutationsin the liver of transgenicgpt delta mice.5 Mutations in β-cateninwere found as an early event in liver tumors of mice treated withME.6 Furthermore, ME increased the mutationalburden in hepatocellular carcinomas of mice in a dose-dependent manner,7 leading to mutational signatures similar to thosein human hepatocellular carcinomas with known exposure to the carcinogensaflatoxin or benzo[a]pyrene.8 In a recent study, it was shown that ME caused DNA damage-dependentreplication stress resulting in mitochondrial apoptosis via the p53-Baxpathway.9 Here, TP53 is linked to hepatocellular carcinoma.