Associations of Anti-CCP2, RF-IgA, and RF-IgM antibodies with left ventricular (LV) ejection fraction, LV mass, LV end diastolic volume, and LV end systolic volume in MESA participants with extremely high reactivity to ≥ 1 citrullinated protein/peptide antigen and free of RA. Here, CD40LG is linked to rheumatoid arthritis.