TP53 and telomere syndrome: Fe cluster A was correlated with α interferon (Enrichment score (ES) = 0.50, FDR = 0), γ interferon (ES = 0.36, FDR = 0.001) and p53 pathway (ES = 0.27, FDR = 0.034) while WNT signaling (ES = −0.54, FDR = 0) and angiogenesis (ES = −0.55, FDR = 0) were related to Fe cluster B. These results were consistent with the result of survival analysis, which also proved that different ferroptosis modification patterns affected the prognosis of STS significantly.