Combination therapy elicited dramatic changes in both the myeloid and lymphoid compartments of the tumor microenvironment, including decreased infiltration of neutrophils and Arg1+ macrophages and increased infiltration of eosinophils, NK cells, CD8+ T cells, and CD4+ T cells (Figure 7, E and G, and Supplemental Figure 7B). This evidence concerns the gene CD8A and neoplasm.