BRCA1 and neoplasm: Differentially expressed transcripts were selected for validation based on their role during vascular endothelial and smooth muscle cell homeostasis, angiogenesis, and tumorigenesis in multiple organ systems and represented pathways including p53/DNA repair/autophagy/tumor suppression (BRCA1, BRCA2, BRIP1, DRAM1, FoxM1) (48–50), oxidant stress and cell senescence (SOD2), and cell motility/inflammation (HMMR) (Figure 2C, Supplemental Figure 1F, and Supplemental Figure 4A).