In contrast to treatment of mice with H/L, HFD in isolation induced neither hypertrophy nor significant CD45+ and CD4+ LV cell infiltration, compared with STD, whereas exclusive exposure to l-NAME did not cause LV hypertrophy compared with STD, despite triggering increases in CD45+ and CD4+ cardiac-infiltrating cells (Supplemental Figure 1, N–P). The gene discussed is CD4; the disease is cardiac hypertrophy.