Activating mutations in the large, multidomain, leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson’s disease and lead to the phosphorylation of a subset of Rab GTPases (Alessi and Sammler, 2018; Vides et al., 2022; Pfeffer, 2023), particularly Rab8A and Rab10 (Steger et al., 2016; Steger et al., 2017). This evidence concerns the gene LRRK2 and Parkinson disease.