CD4 and posterior cortical atrophy: In addition, theNPs reprogrammed M2 macrophages by silencing CSF-1R mRNA expression;in turn, the reprogrammed TAMs remodeled the TME, reactivating theinfiltration of CD4+/CD8+ T cells while decreasingthe Tregs level, culminating in PCa cells apoptosis in a PCa bearingmouse model.