CD44 and neoplasm: Numerous interactions with the tumor immune microenvironment increase their potential to metastasize and escape host immune surveillance [5]. TAMs, transglutaminase 2 (TGM2), a cluster of differentiation 44 (CD44), Epithelial cell adhesion molecule (EpCAM), and vimentin promote tumor growth and metastasis by supporting the infiltration and activity of effective immune cells and facilitating CTCs extravasation at the site of metastasis.