HMOX1 and schizophrenia: It has also been shown that factors associated with the development of schizophrenia, such as ischemia, the presence of pro-inflammatory cytokines, and overproduction of dopamine, induce the gene encoding heme oxygenase 1 (HMOX1), which is associated with disturbed redox homeostasis and dysfunction of mitochondria in neurons in the prefrontal cortex of patients with schizophrenia.