Interestingly, unlike reported previously for innate immune cells such as macrophages and neutrophils in in vivo models of cerebral malaria and autoimmune encephalomyelitis [23], Usp15 knockdown did not affect expression levels of its downstream nodes with or without LPS treatment (Irf7 and Oasl2; Fig. 6c two-way ANOVA, factor siRNA application ns; suppl. The gene discussed is IRF7; the disease is cerebral malaria.