Interestingly, human umbilical cord MSC-EXOs was also found to exhibit desirable therapeutic effects on acetaminophen-induced ALI in vivo and in vitro via dwindling oxidative stress-induced inflammation and apoptosis after activating extracellular regulated protein kinases 1/2 and phosphoinositide 3-kinase/protein kinase B (PI3K/ AKT) trajectories (Wu et al. 2021). Here, AKT1 is linked to acute respiratory distress syndrome.