TGFB1 and hydrops fetalis: Moreover, AD-MSC-EXOs-secreted miR-181-5p was shown to block STAT3/Bcl-2/Beclin1 pathway and increase autophagy, hence decreasing transforming growth factor-beta1 (TGF-β1)-induced HSCs activation with consequent hindrance of HF (Qu et al. 2017).