MSH2 and cancer: Immunohistochemistry revealed the classic dMMR finding with loss of MSH2/MSH6 in MSH2 mutation carriers and isolated loss of MSH6 in MSH6 mutation carriers throughout all respective primary cancers (2 × colon, 2 × rectum) and in the seven other tumors (clear cell type EC with metastasis, urothelial cancer, adrenal cancer with metastasis, 2 × sarcoma).