p.F152I, p.G170R, p.I244T, and c.33dupC were common mutations in Europe PH1 patients, located in AGXT exons 1, 4, and 7, accounting for more than 50% of alleles; And p.G170R was found in more than 50% of American PH1 families. Here, AGXT is linked to primary hyperoxaluria type 1.