Reciprocally, it has been reported that components of the autophagy machinery (MAP1-LC3, ATG5, ATG7) are required for LD biogenesis; MAPLC31 in prostate cancer cells (12, 13) and hepatocytes (17), ATG5 in mouse embryonic fibroblasts (18), ATG5 and 7 in adipocytes (20). The gene discussed is ATG5; the disease is prostate carcinoma.