Critically, this included infection-dependent induction of specific interleukins (e.g., IL17, IL15, and IL20) and other genes associated with a type-I IFN response previously noted to exhibit HCEC-specific expression (Fig. 1B, Fig. 2A), such as IFITM1 (lFC, 7.56), BST2 (logFC, 6.63), IFI44L (FC, 7.00), and CXCL10 (FC, 112.38). The gene discussed is IL15; the disease is infection.