Further antibody penetration analysis via confocal z-stacking analysis of the expression and location of LPR6, PCDHB10, and PCDHB15 targets showed that LRP6 was uniformly distributed within the tumour spheroid, whereas PCDHB10 and PCDHB15 localised from the second bilayer of cells to the core of the spheres (Figure 7). The gene discussed is PCDHB15; the disease is neoplasm.