Another meta-analysis showed that an increased pretreatment of CRP indicates poor prognosis in head and neck squamous cell carcinoma, yet other data have not supported an association between preoperative CRP values and the development of recurrence or metastases, and also, CRP increase during concurrent chemoradiotherapy is a poor predictive marker for head and neck cancer [859,860,861]. Here, CRP is linked to head and neck squamous cell carcinoma.