CRP at the time of diagnosis (>12 mg/L) has been reported as a novel indicator for the prognosis of cases with perihilar extrahepatic cholangiocarcinoma, and elevated pre-operative CRP has been associated with poor clinical outcomes in intrahepatic cholangiocarcinoma patients who underwent hepatectomies with regional lymphadenectomies, yet another study concluded that CRP is a promising immunohistochemical marker to differentiate intrahepatic cholangiocarcinoma from other adenocarcinomas, and its expression was correlated with better prognosis [829,830,831]. This evidence concerns the gene CRP and intrahepatic cholangiocarcinoma.