A recent systematic review on Amyotrophic Lateral Sclerosis (ALS) concluded that CRP seems to be a promising prognostic biomarker, but extensive cohort studies are required to evaluate its prognostic value and accuracy; and a study proved that CRP was as a prognostic biomarker of ALS (elevated CRP > 2 mg/L), yet a Mendelian randomization study concluded that genetically predicted CRP levels may not be an ALS causal risk factor [575,576,577]. Here, CRP is linked to amyotrophic lateral sclerosis.