CRP and systemic lupus erythematosus: Moreover, CRP genetic polymorphisms can affect other nearby genes; in humans, the serum amyloid P component gene and CRP gene map to 1q23.2 within an interval linked to Systemic Lupus Eruthrematosis (SLE) as well as a polymorphism related to decreased basal CRP, was also associated with the development of SLE [57].