Moreover, a study found that CRP concentrations prior to systemic treatment possibly have a prognostic significance and may enable better risk stratification for cases with metastatic urothelial cancer of the bladder, and other data indicate that increased preoperative CRP is linked to worse outcomes in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder [837,838]. This evidence concerns the gene CRP and bladder transitional cell carcinoma.