Old data have shown that CRP seems to be undetected in hepatitis C, and recent evidence has demonstrated that the pooled mean CRP level was within the normal range in cases with hepatitis C; however, it was higher in hepatitis B cases, suggesting that CRP expression correlates with hepatitis B disease progression, but not in chronic hepatitis C, and there is also a possibility that cytokine-mediated response is more pronounced in chronic hepatitis B compared to chronic hepatitis C [938,939,940]. This evidence concerns the gene CRP and hepatitis B virus infection.