Additionally, it was discussed in old data that CRP estimations may aid in ascertaining active melioidosis since an increase in CRP to > 10 mg/L led to the diagnosis of the reactivation of infection in three afebrile individuals, but a following study concluded that CRP is not a sensitive marker for the presence of melioidosis, and that a normal level cannot be assessed to exclude acute, chronic, or relapsed melioidosis in febrile cases in/from endemic regions [989,990]. Here, CRP is linked to infection.