Data regarding headache or migraine and CRP seem controversial; despite some studies that result in no association, a possible epidemiological relation between elevated CRP titers (10–20 mg/L) and migraine has been revealed, yet a study found that the integrity of CRP seems not to be a biomarker of episodic/chronic migraine, and also, another large-scale study found that increased hsCRP was associated with headaches lasting ≥7 days/month, which was particularly evident for migraine with aura [564,565,566,567]. This evidence concerns the gene CRP and Headache.