CRP and cancer: It is worthwhile to add that a major limitation of mass spectrometry (that has been applied to determine CRP molecular weight) is that it cannot reliably aid in tracing the real origin of the tryptic peptides in order to determine which genes really code for the proteins that were detected in the analyzed sample, and also, the initial SDS-gel electrophoresis and AA analysis for CRP was based on a CRP purification by samples of cancer cases, which actually have a higher serum load of aggregated protein-/immunocomplexes, and some of them can be also lipid-bound.