Apart from autoantibodies against CRP that were previously discussed in both antiphospholipid syndrome and SLE, hsCRP was found to have a predictive role and also to be higher in those with secondary antiphospholipid disease (compared to primary state); whether it evolves into SLE or not, the literature reveals that SLE individuals have elevated CRP, including in remission periods, yet its response during flares seems to be incomplete and not always linked to disease activity [704,705,706]. Here, CRP is linked to systemic lupus erythematosus.