Increased baseline CRP concentrations have been linked to shorter survival and the development of second cancers in cases with chronic lymphocytic leukemia, and a study found no significant differences in CRP levels between acute lymphoid and myeloid leukemia that can be useful as an indicator for disease course, and that they were was reduced after treatment, while another study in acute myeloid leukemia and myelodysplastic syndromes found that transplant-related mortality was linked to the pre-specified threshold of CRP > 10 mg/L [779,780,781]. This evidence concerns the gene CRP and B-cell chronic lymphocytic leukemia.