CRP > 150 mg/L has been linked to higher rates of complicated diverticulitis, mortality, and the need for intervention, and also, a systematic review highlighted that comorbidities, non-steroid anti-inflammatory therapy, initial presentations, and baseline CRP > 175 mg/L seem to be predictive of a more severe disease process with a higher possibility for complications and resultant prolonged clinical course; nevertheless, other data have shown that low CRP does not exclude complications [934,935]. The gene discussed is CRP; the disease is diverticulitis.