Except for the relation of CRP and age-related cognitive impairment, it was previously discussed that mCRP can possibly induce the cellular pathology of Alzheimer’s Disease (AD); nevertheless, data on AD seem controversial since a large study and a Mendelian randomization revealed a causal association between genetically elevated CRP and reduced risk for AD, while another study reported that genetically predicted increased CRP may be a causal risk for AD [578,579,580]. This evidence concerns the gene CRP and early-onset autosomal dominant Alzheimer disease.