CRP and cancer: Although higher hsCRP may be linked to a higher risk for colon, but not rectal, cancer, prediagnostic CRP is associated with a higher risk of colorectal cancer, but a Mendelian randomization analysis found that that circulating CRP is unlikely to be a causal factor in colorectal cancer, and also, other data indicate that notably elevated CRP is associated with colorectal cancer mortality [778,824,825].