When the bacteriologist Oswald Avery (who isolated DNA as the material of which genes and chromosomes are made) joined the Rockefeller Institute in 1913, he directed a considerable effort in his lab to understand pneumonia and its supposed most common etiologic agent, Streptococcus pneumoniae, generally referred to at the time as the pneumococcus, and over the course of these studies, CRP was discovered, although one could rather say they blundered into it [1209]. Here, CRP is linked to susceptibility to pneumonia measurement.