CRP and bacterial infectious disease: Old literature sources reveal that in patients suspected of having been infected by a pathogenic agent, CRP levels of up to 100 mg/L are compatible with all bacterial, viral, fungal, and protozoal infections, and also, CRP response can be delayed >12 h, even in subjects with severe acute infections, with peak concentrations mostly reached at 3d post-symptomatology; Moreover, CRP is possibly reliable for the exclusion of bacterial infection, since two values <10 mg/L and 8–12 h apart can be taken to rule out bacterial infection [890].