CRP and obesity due to melanocortin 4 receptor deficiency: Despite the fact that some studies have possibly linked CRP in Bipolar Disorder (BD) cases with underlying medical conditions or obesity, a recent study revealed that mean CRP levels were notably elevated in BD adolescents relative to those with anxiety issues and no psychiatric conditions; the mean CRP levels were lower in those with anxiety compared to those with no issues, and although CRP was significantly higher in males and younger individuals, the important between-cohort CRP differences remained after controlling for multiple confounders [620,621,622,623].