A study on three lupus nephritis patients demonstrated that anti-mCRP antibodies purified from IgG fractions by affinity chromatography could significantly inhibit the binding of mCRP with C1q or factor H, and eliminate late apoptotic cell clearance enhanced by mCRP, suggesting that anti-mCRP antibodies from lupus nephritis patients might be pathogenic in SLE and lupus nephritis via interfering with the biofunctions of mCRP [165]. Here, CFH is linked to lupus nephritis.