Furthermore, a study reported that two different patient sera, one (chronic hepatitis C) with Waldenström’s disease and the other (purpura) with polyclonal hypergammaglobulinemia, had marked discrepancies between their CRP results, and it was found that these discrepancies were caused by milky turbidity produced by the non-specific reaction between high-molecular-weight components, referred to cryoglobulin, composed from IgM-IgG in Waldenström disease and immunocomplexes in polyclonal hypergammaglobulinemia [1179]. Here, CRP is linked to chronic hepatitis C virus infection.