In 1985, Frank A. Robey and colleagues reported anti-CRP antibodies in one out of eight Systemic Lupus Erythematosus (SLE) cases and a reduced CRP ability to solubilize chromatin in certain SLE cases, whereas other scientists reported a high frequency of antibodies to cryptic epitopes of CRP in patients suffering from toxic oil syndrome—a condition resembling SLE. Here, CRP is linked to systemic lupus erythematosus.