Concerning rheumatoid arthritis (RA), mCRP was found to modulate the differentiation of osteoclasts in a conformational RANKL-dependent manner; it actively controls osteoclast differentiation via NF-κB and phospholipase C signaling, and can bind to RANKL, the major driver of osteoclast differentiation, and abrogate its activities through its cholesterol-binding sequence [102]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.