CRP may show divergent values in chronic spontaneous urticaria (median 4.5 mg/L, and approx. 36 mg/L in another study); it can be elevated in 1/3 of cases, and it can also be correlated with treatment efficacy, while other authors have demonstrated that CRP levels were higher in those with a positive autologous serum skin test, concluding that autoimmune urticaria is characterized by low-grade inflammation, while other data have found no association between CRP and the condition [463,464,465,466,467]. The gene discussed is CRP; the disease is chronic idiopathic urticaria.