Finally, except for acute bronchiolitis, serum CRP has also been elevated in Bronchiolitis Obliterans Syndrome (BOS) three years post lung transplantation, but only Bronchoalveolar Lavage (BAL) CRP was an independent predictor of graft failure, suggesting that baseline BAL or plasma CRP level may be predictive of post lung transplantation long-term outcomes, and also, even if the precise role of CRP in BOS were not detected, it was demonstrated that local CRP regulated inflammatory components and allograft rejection [318,319]. The gene discussed is CRP; the disease is Buschke-Ollendorff syndrome.