In a previous, wide-ranging study, Schoenfeld et al. analysed various cohort studies and concluded that epidemiologic studies so far have implied a link between the classic risk factors for CVD (hyperlipidaemia, cigarette smoking, advanced age, arterial hypertension, male sex, and elevated C-reactive protein) and the increased risk for CVD in patients with systemic lupus erythematosus (SLE). The gene discussed is CRP; the disease is Hypertension.