One of the F-box proteins, BTRC, also called β-TrCP, has been demonstrated to regulate cellular processes by recognizing numerous essential molecules, including IκBα and β-catenin, for degradation and play a significant role in cancer development and inflammation (Frescas and Pagano, 2008; Lau et al., 2012; Bi et al., 2021). Here, NFKBIA is linked to cancer.