DNAJC8 and Spinocerebellar ataxia type 3: (Guzman-Ruiz et al., 2020; Pulido et al., 2011) Another example is DnaJC8 protein, the effect of which is closely associated with the aggregation of polyQ-containing proteins in a cellular model of spinocerebellar ataxia type 3 (SCA3).(Ito et al., 2016) The authors have shown that DnaJC8 overexpression significantly reduces polyQ aggregation and apoptosis.