FLT3 and acute myeloid leukemia: This genetic alteration at the DNA level has significant implications for the function and activation of the encoded protein, influencing its role in AML pathogenesis [8,9].To better understand the structural alterations caused by FLT3 mutations, Figure 1 provides a schematic representation of FLT3 and highlights the positions of FLT3-ITD and FLT3-TKD mutations within the receptor.