If the following conditions were satisfied, nephrotoxicity was determined: 1. An increase in serum creatinine of 0.3 mg/dL within two days, 1.5 to 1.9 times baseline within seven days, or 0.3 mg/dL but within normal limits is also a sign of significant renal damage because the usual range is between 0.5 and 1.5 mg/dL. 2. Hypouricemia as observed in Fanconi syndrome affects the proximal tubules (normal values: 2.6–6.0 mg/dL). 3. Unusual grades of +1 and +2 for the albumin-creatinine ratio in spot urine. 4. Anemia (normal hemoglobin for women is 12 and for men is 13). This evidence concerns the gene ALB and Fanconi renotubular syndrome.