GPC-6: glypican-6, NT-ProBNP: N-terminal pro-B-type natriuretic peptide, EF: ejection fraction, HFrEF: heart failure with reduced ejection fraction, HFmrEF: heart failure with mildly reduced ejection fraction, HFpEF: Heart failure with preserved ejection fraction. The gene discussed is NPPB; the disease is heart failure.