CTCF and acute myeloid leukemia: In AML, a recent study from Xu and colleagues performed multiomics [HiC, RNAseq, ATACseq, Cleavage Under Targets and Tagmentation (CUT&TAG) for CTCF, H3K27ac, H3K27me3] from the same AML samples in 25 AML samples and 7 normal donors, combined with whole genome sequencing to analyse copy number‐ and structural variations that could further impact the epigenome [36].