KMT2A and acute myeloid leukemia: In a set of eight primary AML samples and some exemplar AML cell lines with rearrangements of the KMT2A (MLL1) locus (MLLr), Janssens, Henikoff and colleagues, successfully applied an sc‐CUT&TAG approach to map differential genomic binding of KMT2A (wt or mutated) together with profiles for the H3K4me3 and H3K27me3 histone modifications [37].