This is also the case for 8/14 syndromic HCM (CACNA1C, FLNC, PRKAG2, PTPN11 (Noonan), PTPN11 (Noonan syndrome with multiple lentigines), RAF1, RIT1, TTR), 3/12 DCM (DES, TNNC1 and TNNT2), and 2/6 ARVC (JUP, TMEM43) gene-disease pairs. Here, TMEM43 is linked to Noonan syndrome with multiple lentigines.