However, 3/6 ARVC genes demonstrate both autosomal dominant and recessive inheritance; JUP-related Naxos disease (a syndrome characterised by ARVC, woolly hair, and palmoplantar keratoderma) is exclusively inherited in an autosomal recessive manner, and 3/14 syndromic HCM genes (FHL1, GLA and LAMP2) are X-linked. Here, GLA is linked to hereditary palmoplantar keratoderma.