Similarly, although the phenotype most frequently shown by patients with CALM pathogenic variants is LQTS, others display CPVT and sudden unexplained death and some CALM variants have been associated with both LQTS and CPVT, without evidence of distinct mechanisms underlying different phenotypic manifestations [49, 52]. This evidence concerns the gene CALM1 and catecholaminergic polymorphic ventricular tachycardia.