FAM227B was identified in the E/pf dataset (Log2 FC = 1.675 in GRCh38.p14, Log2 FC = −0.007 in T2T-CHM13v2.0), and LOC105375228 was detected in the ALS/sc dataset (Log2 FC = −1.470 in GRCh38.p14, Log2 FC = −0.072 in T2T-CHM13v2.0). Here, FAM227B is linked to amyotrophic lateral sclerosis.