Our study suggests that Nrf2 gene overexpression (Blood PCs 0.28%, Blood PC 0.92%; Kidney PCs 5.75%, Kidney PC 2.06%) regulates TLR4+CXCR4+ PCs and PC levels in the blood and kidneys of a mouse model of lupus, with concomitant amelioration of damaged tissue. Here, CXCR4 is linked to systemic lupus erythematosus.