KCNH8 and amyotrophic lateral sclerosis: Around the locus rs6801884 were two protein-coding genes KCNH8 and SATB1. Functionally, KCNH8 encodes a voltage-gated potassium channel that is primarily expressed in the nervous system, and plays a role in transmission pathways across chemical synapses and potassium channels, which is closely involved in the pathogenesis of ALS [40].