At the same time, the most significant differentially expressed antigen between AML blasts and normal CD34+ hematopoietic precursors was U5 snRNP200, as this antigen (originally identified as a potential AML-specific antigen in prior work15) was totally absent from normal HSCs, multipotent progenitors (MPPs) and any downstream myeloid progenitor population (Fig. 1c). Here, CD34 is linked to acute myeloid leukemia.