Specifically, in the TTS patients, we observed enrichment of markers of severe COVID-19 (P = 1.38E-161)18, blood coagulation (P = 5.62E-23), activation of complement (P = 1.13E-21), platelet (P = 1.05E-09), neutrophil (P = 2.07E-07), MAIT cell activation (P = 0.00008), macrophage (P = 0.0001), inflammatory response (P = 0.0008), TNF signaling via NF-κB (P = 0.0009), and IL6 JAK STAT3 signaling (P = 0.001). Here, TNF is linked to COVID-19.