CTNNB1 and adenoma: If adenoma would be detected by biopsy and its FAP-related nature can be clarified by APC-gene sequencing, according to current knowledge, resection criteria may not adhere to criteria for beta-catenin-activated HCA (resection at any size) but to general HCA criteria (resection > 5 cm), and even a “watch and wait” strategy may be considered [40].