IFNG and infection: Conversely, treatment with IRF5 inhibitor N5-1 significantly increased fungal burden in the kidneys and brains of Clec2dfl/flLyz2Cre/+mice, accompanied by decreased levels of IL-12 and IFN-γ in the kidneys of Clec2dfl/flLyz2Cre/+mice on Day 1 after infection with C. albicans (Fig. 7g, h).