CDK6 and hepatocellular carcinoma: Gene set enrichment analysis (GSEA) of The Cancer Genome Atlas (TCGA) demonstrated that the Wnt/β-catenin signaling pathway was significantly enriched in HCC patients with high CDK6 expression, which further confirmed Wnt/β-catenin as the major effector of CDK6 signaling in the in vitro findings (Fig. 7e).