CD8A and colitis: Analysis of the main lymphocyte lineages identified remodelling of the transcriptome in T cells and B cells (Fig. 5d and Supplementary Fig. 11a), with significant upregulation (Bonferroni corrected P value < 0.001) of Ifng, Gzmb, Gzma, Nkg7, and the chemokines Ccl3, Ccl4 and Ccl5 in both CD4+ and CD8+ T cell compartments in CPI-induced colitis (Fig. 5d).