CD8A and colitis: To further evaluate the phenotype of Ifng-expressing lymphocytes in CPI colitis, we compared chemokine and gut-homing receptors in cells in comparison with lymphocytes that do not express Ifng. In both CD4+ cells and CD8+ T cells, the most upregulated chemokine receptor was Cxcr6 (6.3-fold, FDR = 2.1 × 10−105 in CD4+ T cells and 2.2-fold, FDR, and 3.6-fold, 1.1 × 10−19 in CD8+ T cells), and in the case of CD8+ T cells, Cxcr6 was the only upregulated chemokine receptor (Fig. 7b and Supplementary Fig. 16a, b).