SYK and colitis: The network identified activation of transcription factors (STAT3, NFATC1, T-bet), MAP kinase pathways (ERK1/2, p38 MAPK), signalling molecules (Phospholipase C gamma 2) and other kinases (PRKCD, Syk) implicated in inflammatory diseases (Fig. 8j), providing a potential regulatory roadmap for IL23-mediated regulation of IFN-expressing T cells in CPI colitis.