The SPPL3 intronic variant rs2393717 G allele (frequency 47.3% in EUR) associated with increased TSH was associated with reduced hypothyroidism risk, increased tyrosine (a thyroid hormone precursor), as well as decreased C-reactive protein, increased insulin-like growth factor 1 (IGF-1), reduced height, whole body fat-free mass and reduced sex hormone binding globulin (especially in males), decreased gamma glutamyltransferase (GGT), increased alkaline phosphatase, reduced platelet count and eosinophils, increased cholesterol and with lipid composition traits. Here, IGF1 is linked to hypothyroidism.