TRMO and thyroid gland carcinoma: C9orf156 (encoding TRNA Methyltransferase O) was implicated by a single putative causal tolerated missense variant, rs2282192 (T allele, frequency 28.8% in EUR), associated with increased TSH, increased hypothyroidism risk and decreased risk of nontoxic multinodular goitre and thyroid cancer as well as lower mean corpuscular volume and HbA1c.