However, tolerated SH2B3 missense variant, rs3184504 (allele T), associated with increased TSH, was associated with increased risk of both hypothyroidism and hyperthyroidism, and in our PheWAS with increased risk of other autoimmune disorders and pleiotropic associations with many traits (Supplementary Data 5 and 6). This evidence concerns the gene SH2B3 and hypothyroidism.