The G allele of the APOH missense deleterious variant, rs1801690 (MAF 5.7% in EUR), was associated with reduced TSH, increased risk of hyperthyroidism, increased risk of congenital anomalies of endocrine glands and thyrotoxicosis in the UK Biobank DeepPheWAS analysis, as well as increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, increased height, reduced triglycerides, reduced carotid intima media thickness and, in FinnGen16, reduced deep venous thrombosis risk. Here, GPT is linked to thyrotoxicosis.