The GRS for higher TSH specific to the cAMP signalling pathway (KEGG, including novel genes GNAS, PDE4D, PDE4B, ADCY6, CGA) was specific to increased risk of hypothyroidism; no associations (FDR < 1%) with other traits were shown (Supplementary Fig. 4a). The gene discussed is PDE4D; the disease is hypothyroidism.