GRSs specific to several pathways showed association to PheCode 244.1 capturing consequences of treated hyperthyroidism: the ALK in cardiac myocytes pathway, pathways in cancer (KEGG), factors and pathways affecting IGF-1-Akt signaling (Wikipathways), myometrial relaxation and contraction pathways (Wikipathways), FGFR3 signaling in chondrocyte proliferation and terminal differentiation (Wikipathways). The gene discussed is AKT1; the disease is hyperthyroidism.