The protein products of these genes include targets for treatments to stimulate (thyrotropin [TSH]) or suppress (methimazole, targeting thyroid peroxidase, TPO) thyroid function, and drugs to treat thyroid cancer (e.g. the KDR inhibitor, vandetanib) as well as PDE4 inhibitors and AKT inhibitors utilised in immunoinflammatory conditions and cancers (Supplementary Data 8). The gene discussed is KDR; the disease is cancer.