SPPL3 and hypothyroidism: The SPPL3 intronic variant rs2393717 G allele (frequency 47.3% in EUR) associated with increased TSH was associated with reduced hypothyroidism risk, increased tyrosine (a thyroid hormone precursor), as well as decreased C-reactive protein, increased insulin-like growth factor 1 (IGF-1), reduced height, whole body fat-free mass and reduced sex hormone binding globulin (especially in males), decreased gamma glutamyltransferase (GGT), increased alkaline phosphatase, reduced platelet count and eosinophils, increased cholesterol and with lipid composition traits.