The 30 genes supported by ≥3 criteria include genes involved in transcriptional regulation (BNC2, HMGA2, PHC2, TSHZ3, GLIS3), production, signaling or response to thyroid hormones (TG, TPO, TSHR, PDE4D) or non-thyroid hormones (ADCY6, INSR, NR3C2), regulation of thyroid-relevant pathways (HMGA2, IGFBP5), neuronal protection and neuropathies (ADCY6, TRIM2), angiogenesis (SMOC2, SKG1, VEGFC, SPATA13), AKT signalling (PTEN, SGK1, AKT1, PTPRS) and ciliogenesis (SDCCAG8). The gene discussed is PDE4D; the disease is neuropathy.