METTL3 and non-small cell lung carcinoma: To further explore the effect of METTL3/IL-18 axis on immunosuppression of NSCLC, as showing in Figure 4a,b, IL-18 was highly expressed in A549 and H1650 cells which were co-cultured with CAF-CM, and METTL3-knockdown in CAFs enhanced the facilitation, but IL-18 binding protein (IL-18BP) antagonized the effect of METTL3-knockdown in CAFs IL-18 binding protein (IL-18BP) specifically interacts with IL-18, thereby playing a negative regulatory biological activity of IL-18 [30].