CD4 and neoplasm: Analysis of the lymphocyte interactome from both treatments revealed increased tumor interactions of CD8+ T cells, NK cells, and to a lesser extent CD4+ T cells and Tregs, compared to negligible interactions among γδ T cells, NKT Cells, ILCs, and B cells (Fig. 4 D and E; see SI Appendix, Fig. S4 B and C).