It remains to be seen whether an understanding of the opposing roles of ENPP1 in the suppression of ectopic mineralization and maintenance of bone mass will unlock the treatment of CKD-MBD patients, but efforts to this end are currently being explored, including a natural history study in calciphylaxis patients demonstrating that their plasma PPi levels are comparable to levels observed in GACI patients and correlate with mortality. The gene discussed is ENPP1; the disease is Marchiafava-Bignami disease.