To our interest, supplementation of exogenous cholesterol in nonalcoholic steatohepatitis has been shown to help in mitigating the toxic effects of bile acid and lipids by enhancing the expression of NRF2 (Nuclear Factor-Erythroid 2- related factor 2) and HIF-1α (Hypoxia Inducible Factor 1) [50]. This evidence concerns the gene HIF1A and metabolic dysfunction-associated steatohepatitis.