SIRT6 and infection: First, we found that Mtb H37Rv infection of mouse peritoneal macrophages induced the expression of the histone modifiers HMT G9a (encoded by Ehmt2) and HDAC SIRT6 (encoded by Sirt6) 12 h post infection at protein as well as transcript level (Fig 1A and 1B). Interestingly, enhanced expression of G9a and SIRT6 did not affect the global histone H3K9 monomethylation and H3K9 acetylation pattern respectively (S1A Fig).