Interestingly, perturbation of WNT, G9a, SIRT6, cholesterol accumulation genes or antioxidant genes, was found to restrict Mtb burden in vitro and lack of G9a or SIRT6 was also found to limit Mtb growth and lung pathology in an in vivo mouse model of tuberculosis (TB); thereby suggesting the targeting of these epigenetic factors as potential adjuvants for TB therapy. The gene discussed is SIRT6; the disease is tuberculosis.