NFE2L2 and metabolic dysfunction-associated steatohepatitis: To our interest, supplementation of exogenous cholesterol in nonalcoholic steatohepatitis has been shown to help in mitigating the toxic effects of bile acid and lipids by enhancing the expression of NRF2 (Nuclear Factor-Erythroid 2- related factor 2) and HIF-1α (Hypoxia Inducible Factor 1) [50].