These findings were validated at the protein level, where G9a inhibitor limited the surface expression of LRP2 during infection, both in vitro(Fig 2E and 2F) and in vivo(Fig 2G); and ABCA1 protein expression was found to be elevated in the lungs of Mtb H37Rv-infected Sirt6−/+ mice (Fig 2H), compared to that in the infected wild type controls. The gene discussed is ABCA1; the disease is infection.