TMPRSS2 and colorectal carcinoma: In turn, in BRAF-mutant CRC cells, ZEB1 downregulation increased HOOK1 and ARHGAP4 (cytoskeletal organizers) and FGF4 (cell death) expression while it reduced DSC2 and TFF2 (cell adhesion), TMPRSS2 (cytoskeletal organizer), PYCARD (cell death), and EHF expression (Figure 6E).