MUC5AC and adenoma: Relative to tumors in KVZ+/+ mice, tumors in KVZ+/– mice exhibited lower levels of nuclear β-catenin (a marker of aberrant Wnt signaling), Alcian blue (an acidic mucin marker of goblet cells), and lysozyme (a Paneth cell marker, which is upregulated in adenomas and carcinomas; ref. 47) (Figure 2B).