FAM3C and colorectal carcinoma: Several DEG that appeared commonly modulated by ZEB1 in KRAS- and BRAF-mutant CRC cells in the RNA-Seq were validated by quantitative real-time PCR (qRT-PCR); for instance, the downregulation of ZEB1, KRAS, or BRAF reduced mRNA levels of KLK10, DHRS2, PRDX3, and BABAM1, whereas it upregulated FAM3C mRNA (Figure 6E).