To examine the role of ZEB1, we crossed both CRC models with either Zeb1+/+ (Z+/+, WT) mice or with Zeb1+/– mice (Z+/–) (39) to generate the 4 experimental models, namely KrasLSL-G12D; Vil1Cre; Zeb1+/+ (referred to hereafter as KVZ+/+), KrasLSL-G12D; Vil1Cre; Zeb1+/– (KVZ+/–), BrafLSL-V600E; Vil1Cre; Zeb1+/+ (BVZ+/+), and BrafLSL-V600E; Vil1Cre; Zeb1+/– (BVZ+/–). Here, ZEB1 is linked to colorectal carcinoma.