Some genes were regulated by ZEB1 specifically in either KRAS or BRAF-mutant CRC cells; for instance, in KRAS-mutant CRC cells, ZEB1 downregulation increased CDC25A expression and reduced that of ADAM17 (involved in catabolic or proteolytic processes), MDM2, CENPF, DICER1, and TICAM2 (involved in cell division). The gene discussed is ADAM17; the disease is colorectal carcinoma.