Likewise, JMJD2A was methylated in 3 other cell lines tested: embryonic kidney 293T, LNCaP prostate cancer and HCT116 colorectal cancer cells (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.164990DS1). The gene discussed is KDM4A; the disease is Familial prostate cancer.