ITGB4 and Familial prostate cancer: We then selected differentially expressed genes known to promote (MMP1, MMP14, EPCAM, ITGB4, PLAU) or inhibit (FBLN1, RNASEL) prostate cancer cell invasion and/or proliferation (see Discussion) and validated the RNA-Seq data by RT-PCR for these genes (compare Figure 5B with Figure 5D).